SeqDYN: Predictor for the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

Method at a Glance

SeqDYN is a sequence-based method for predicting the NMR transverse relaxation rates of individual residues in an intrinsically disordered protein. For a central residue n, every other residue i contributes a multiplicative factor f(i; n), which depends on the amino-acid type of residue i and the sequence distance |i-n|.

Reference:

S. Qin and H.-X. Zhou, Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins, eLife 12:RP88958

Prediction

Enter the IDP (or IDR) sequence to get predicted transverse relaxation rates (R₂)

Output

Name:

Seqence:

Data

1st column, amino acid; 2nd column, predicted R₂ (in s^-1)
[Note: a uniform scaling factor may be required to get best match with measured results. The scaling factor typically ranges from 0.8 to 2. Higher scaling usually applies to measurements at low temperatures (e.g., 278 K).]