DIRseq: a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

Method at a Glance

DIRseq is a sequence-based method for predicting drug-interacting residues of an intrinsically disordered protein. For a central residue n, every other residue i contributes a multiplicative factor f(i; n), which depends on the amino-acid type of residue i and the sequence distance |i-n|. The total factor of residue n is then converted to a propensity score via a sigmoid function.

Reference:

Download source code

You can download the javascript code, DIRseq.js, for DIRseq here. To run, use the following command,

    nodejs DIRseq.js PROTEINSEQENCE

where “PROTEINSEQENCE” is the protein sequence in one-letter representation.

Prediction

Enter the IDP (or IDR) sequence to get predicted drug-interacting residues propensity

Output

Name:

Seqence:

Data

1st column, amino acid; 2nd column, propensity of being a drug-interacting residue (on a scale from 0 to 100)


Figure